Chloro-N,N-dialkylamino-2,2,2-trichloro-te/t-butoxy-phosphines, New Reagents in the Syntheses of Oligonucleotides
نویسندگان
چکیده
M anuela Klein, Ivar Ugi* Organisch-Chemisches Institut der Technischen Universität München, Lichtenbergstraße 4. D-85748 Garching, Germany Z. Naturforsch. 50b, 948-952 (1995); receifed November 11, 1994 Oligonucleotides, Phosphite Triesters Chloro-N,N-dimethylaminoand chloro-N,N-diisopropylamino-2.2,2-trichloro-/‘eA-r-butoxyphosphine are demonstrated as reagents in the automated solid-phase oligonucleotide syntheses.
منابع مشابه
2-Chloro-N-(2,6-dimethylphenyl)acetamide
The crystal structure of the title compound (26DMPCA), C(10)H(12)ClNO, is closely related to those of side-chain-unsubstituted N-(2,6-dimethyl-phen-yl)acetamide and side-chain-substituted 2,2,2-trichloro-N-(2,6-dimethyl-phen-yl)-acet-amide and N-(2,6-dimethyl-phen-yl)-2,2,2-trimethylacet-amide, with slightly different bond parameters. The mol-ecules in 26DMPCA are linked into chains through N-H...
متن کاملThree Component Syntheses of Pyrrolo Imidazole Derivatives in the Presence of N-methyl imidazole, Activated Acetylenes and Phenylsulfonylacetophenone
Because of the significant role in biological processes in living cells and the diverse types of physiological activities, heterocyclic compounds are in focus of intense investigations by academic, industry and applied-oriented chemists. Considerably, ascientific renaissance of heterocycles during the last decades is closely related to the development of multicomponent approaches to their s...
متن کامل2,2-Dichloro-N-(3-nitrophenyl)acetamide
The conformation of the N-H bond in the structure of the title compound (3NPDCA), C(8)H(6)Cl(2)N(2)O(3), is anti to the meta-nitro group, similar to that in the structures of 2-chloro-N-(3-nitro-phen-yl)acetamide (3NPCA) and 2,2,2-trichloro-N-(3-nitro-phen-yl)acetamide (3NPTCA), and the meta-chloro group in 2,2-dichloro-N-(3-chloro-phen-yl)acetamide (3CPDCA). The geometric parameters of 3NPDCA ...
متن کاملLFER Studies Evaluating Solvent Effects on an α-Chloro-and two β,β,β-Trichloro-Ethyl Chloroformate Esters
To provide insight and to identify the occurrence of mechanistic changes in relation to variance in solvent-type, the solvent effects on the rates of solvolysis of three substrates, 2,2,2-trichloro-1,1-dimethylethyl chloroformate, 2,2,2-trichloroethyl chloroformate, and 1-chloroethyl chloroformate, are analyzed using linear free energy relationships (LFERs) such as the extended Grunwald-Winstei...
متن کامل4′-Chlorobiphenyl-4-yl 2,2,2-trichloroethyl sulfate
The title compound, C(14)H(10)Cl(4)O(4)S, is a 2,2,2-trichloro-ethyl-protected precursor of 4'-chloro-biphenyl-3-yl sulfate, a sulfuric acid ester of 4'-chloro-biphenyl-3-ol. The C(aromatic)-O and O-S bond lengths of the C(aromatic)-O-S unit are comparable to those in structurally analogous biphenyl-4-yl 2,2,2-trichloro-ethyl sulfates with no electro-negative chlorine substituent in the benzene...
متن کامل